B12 – 10mg
$ 35.00
All products are for laboratory research purposes only. Not for human consumption, medical, or veterinary use. ION Peptides does not condone or support the use of peptides outside of controlled scientific research. By purchasing, you acknowledge that you are a qualified researcher or institution. You must be 21 or older.
B12 – Research Use Only
Research-Grade Vitamin
Tagline: Methylation & Energy Metabolism Research
Product Description
Vitamin B12 (Cobalamin) is an essential, water-soluble vitamin that serves as a cofactor in several critical enzymatic reactions, including DNA synthesis, methylation cycles, and energy metabolism. In research, B12 is commonly studied to understand its roles in neurological function, red blood cell production, and homocysteine metabolism.
Researchers use Vitamin B12 in preclinical models to explore methylation status, one-carbon metabolism, nervous system development, and anemia mechanisms. Different forms (methylcobalamin, cyanocobalamin, hydroxocobalamin, adenosylcobalamin) are used to study specific biochemical pathways.
For Laboratory and Scientific Research Use Only. Not for Human Consumption.
Why Researchers Choose Vitamin B12
Multiple Biologically Active Forms: Allows pathway-specific studies (methylation vs mitochondrial metabolism).
Key Coenzyme Role: Cofactor for methionine synthase and methylmalonyl-CoA mutase.
Methylation Research: Critical for one-carbon metabolism and SAM cycle studies.
Neurobiology Relevance: Studied for its role in myelin synthesis and cognitive health.
Batch Verified: High-purity (≥98%) and identity confirmed for reproducibility.
Important Note
For laboratory and scientific research only. Not for human consumption, veterinary use, or diagnostic purposes.
| Size | 10mg I 20mg |
|---|
| Chemical Formula | C₆₃H₈₈CoN₁₄O₁₄P |
| Molecular Mass | ~1355.4 g/mol |
| CAS Number | 68-19-9 (Cyanocobalamin) |
| Form | Crystalline powder (Cyanocobalamin or Methylcobalamin available) |
| Shelf Life | 24 months (protected from light) |
| Intended Use | For preclinical and in vitro research only |
| Storage | 2–8 °C (refrigerated), desiccated and light-protected |
Research Applications
Methylation & Epigenetic Studies
B12 serves as a cofactor for methionine synthase, converting homocysteine to methionine and supporting DNA methylation [1].
Hematology & Anemia Models
Deficiency studies are used to model megaloblastic anemia and understand red blood cell maturation [2].
Neurological & Cognitive Research
Supports myelin formation and neurotransmitter synthesis; deficiency linked to neurodegeneration [3].
Mitochondrial & Energy Metabolism
Adenosylcobalamin form is a cofactor for methylmalonyl-CoA mutase, involved in odd-chain fatty acid metabolism [4].
References
Green R et al. (2017). Vitamin B12 Deficiency and One-Carbon Metabolism. NEJM.
https://pure.au.dk/portal/en/publications/vitamin-b12-deficiencyO’Leary F et al. (2010). Hematologic Manifestations of B12 Deficiency. Blood Rev.
https://www.mdpi.com/2072-6643/2/3/299Moore E et al. (2012). Cobalamin and Neurodegeneration: Clinical and Preclinical Evidence. Nutrients.
https://europepmc.org/abstract/MED/22221769Hannibal L et al. (2016). Mitochondrial Function and Cobalamin-Dependent Enzymes. Mol Genet Metab.
https://www.degruyterbrill.com/document/doi/10.1515/cclm-2012-0568/pdf
Mechanism of Action (How Vitamin B12 Works)
Cofactor for Methionine Synthase: Catalyzes conversion of homocysteine to methionine, maintaining methylation capacity [Green 2017].
Cofactor for Methylmalonyl-CoA Mutase: Facilitates conversion of methylmalonyl-CoA to succinyl-CoA, critical for energy metabolism [Hannibal 2016].
Supports DNA Synthesis: Required for purine and thymidylate synthesis during cell division [O’Leary 2010].
Maintains Myelin Integrity: Essential for myelin sheath formation and nervous system function [Moore 2012].
Regulates Homocysteine Levels: Helps prevent hyperhomocysteinemia, which is linked to cardiovascular risk [Green 2017].
References
Green R et al. (2017). Vitamin B12 Deficiency and One-Carbon Metabolism. NEJM.
https://pure.au.dk/portal/en/publications/vitamin-b12-deficiencyO’Leary F et al. (2010). Hematologic Manifestations of B12 Deficiency. Blood Rev.
https://www.mdpi.com/2072-6643/2/3/299Moore E et al. (2012). Cobalamin and Neurodegeneration: Clinical and Preclinical Evidence. Nutrients.
https://europepmc.org/abstract/MED/22221769Hannibal L et al. (2016). Mitochondrial Function and Cobalamin-Dependent Enzymes. Mol Genet Metab.
https://www.degruyterbrill.com/document/doi/10.1515/cclm-2012-0568/pdf
