Thymosin Alpha-1
Price range: $ 35.00 through $ 65.00
All products are for laboratory research purposes only. Not for human consumption, medical, or veterinary use. ION Peptides does not condone or support the use of peptides outside of controlled scientific research. By purchasing, you acknowledge that you are a qualified researcher or institution. You must be 21 or older.
Thymosin Alpha-1 (Tα1)
Research-Grade Immunomodulatory Peptide
Tagline: Immune System & Inflammation Research
Product Description
Thymosin Alpha-1 (Tα1) is a 28–amino acid peptide fragment derived from the thymic hormone prothymosin alpha. It is a potent immunomodulatory molecule that enhances both innate and adaptive immune responses.
Researchers use Tα1 in preclinical and in vitro studies to explore immune activation, T-cell function, antiviral defense, and tumor immunology. It is widely studied for its potential to regulate immune tolerance, modulate cytokine production, and restore immune balance in immune-suppressed states.
For Laboratory and Scientific Research Use Only. Not for Human Consumption.
Why Researchers Choose Thymosin Alpha-1
Immune Activation: Enhances T-cell differentiation and NK cell activity.
Broad Research Relevance: Studied in infection, cancer immunology, and vaccine adjuvant research.
Cytokine Modulation: Promotes Th1 response, increases IFN-γ production.
Well-Characterized Peptide: Clinically investigated, with decades of published data.
Batch Verified: ≥98% purity, identity confirmed by HPLC and mass spectrometry.
Important Note
For laboratory and scientific research only. Not for human consumption, therapeutic, or diagnostic use.
| Chemical Formula | C₁₂₉H₂₁₅N₃₃O₅₅ |
| Molecular Mass | ~3108.3 Da |
| CAS Number | 62304-98-7 |
| Form | Lyophilized peptide powder |
| Shelf Life | 24 months (lyophilized) |
| Intended Use | For preclinical and in vitro research only |
| Storage | -20 °C (dry powder), -80 °C (after reconstitution) |
Research Applications
Immune System Stimulation
Tα1 enhances T-cell differentiation, dendritic cell maturation, and NK cell cytotoxicity in immune models [1].
Infectious Disease & Antiviral Research
Shown to boost immune response to viral infections, increasing IFN-α and IL-2 production [2].
Cancer Immunology
Investigated as an immune adjuvant to increase tumor antigen presentation and cytotoxic T-cell response [3].
Autoimmune & Immune Tolerance Studies
Reported to modulate regulatory T-cell activity, restoring immune balance in autoimmune models [4].
References
Goldstein AL et al. (1981). Thymosin Alpha-1: Chemistry and Biological Activity. Ann N Y Acad Sci.
https://www.sciencedirect.com/science/article/pii/S0196978110003384Wang FS et al. (2004). Thymosin Alpha-1 Enhances Antiviral Immunity in Chronic Infection Models. J Hepatol.
https://europepmc.org/article/MED/15546254Garaci E et al. (2000). Role of Thymosin Alpha-1 in Tumor Immunology. Cancer Immunol Immunother.
https://www.sciencedirect.com/science/article/pii/S0192056100000758Romani L et al. (2006). Thymosin Alpha-1 and Immune Regulation in Autoimmunity. Ann N Y Acad Sci.
https://europepmc.org/article/MED/17495242
Mechanism of Action (How Thymosin Alpha-1 Works)
TLR Pathway Activation: Binds to Toll-like receptors (TLR2, TLR9) on dendritic cells and macrophages, triggering innate immune activation [Goldstein 1981].
Th1 Immune Shift: Promotes IL-2 and IFN-γ production, enhancing cell-mediated immunity [Wang 2004].
Cytotoxic T-Cell Support: Increases expression of MHC class I/II molecules, improving antigen presentation [Garaci 2000].
NK Cell Potentiation: Boosts natural killer cell cytotoxicity and anti-viral response [Wang 2004].
Immune Homeostasis: Modulates Treg and Th17 balance, helping restore immune tolerance [Romani 2006].
References
Goldstein AL et al. (1981). Thymosin Alpha-1: Chemistry and Biological Activity. Ann N Y Acad Sci.
https://www.sciencedirect.com/science/article/pii/S0196978110003384Wang FS et al. (2004). Thymosin Alpha-1 Enhances Antiviral Immunity in Chronic Infection Models. J Hepatol.
https://europepmc.org/article/MED/15546254Garaci E et al. (2000). Role of Thymosin Alpha-1 in Tumor Immunology. Cancer Immunol Immunother.
https://www.sciencedirect.com/science/article/pii/S0192056100000758Romani L et al. (2006). Thymosin Alpha-1 and Immune Regulation in Autoimmunity. Ann N Y Acad Sci.
https://europepmc.org/article/MED/17495242
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