MGF – 2mg
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MGF (Mechano Growth Factor)
Research-Grade IGF-1 Isoform
Tagline: Muscle Growth & Repair Research
Product Description
MGF (Mechano Growth Factor) is a splice variant of IGF-1 (Insulin-Like Growth Factor-1) expressed locally in skeletal muscle following mechanical overload or injury. MGF is a potent stimulator of satellite cell activation and muscle regeneration.
Researchers use MGF in studies of muscle hypertrophy, injury repair, regenerative medicine, and age-related muscle decline. Its short half-life provides insight into localized, transient IGF-1 signaling events.
For Laboratory and Scientific Research Use Only. Not for Human Consumption.
Why Researchers Choose MGF
Endogenous IGF-1 Isoform: Allows modeling of natural muscle repair processes.
Muscle-Specific Expression: Studied as a locally acting growth factor for hypertrophy.
Satellite Cell Activation: Key regulator of myoblast proliferation and differentiation.
Short Half-Life: Enables research on transient anabolic signaling.
Batch Verified: ≥98% purity, HPLC and MS-tested for consistency.
Important Note
For laboratory and scientific research only. Not for human consumption, therapeutic, or diagnostic use.
| Chemical Formula | C₁₂₁H₂₀₀N₄₂O₃₉S |
| Molecular Mass | ~2888 Da |
| CAS Number | Not assigned (splice variant peptide) |
| Form | Lyophilized peptide powder |
| Shelf Life | 24 months (lyophilized) |
| Intended Use | For preclinical and in vitro research only |
| Storage | -20 °C (dry powder), -80 °C (after reconstitution) |
Research Applications
Muscle Hypertrophy Studies
MGF expression is upregulated following mechanical overload, promoting local muscle growth and hypertrophy [1].
Injury Repair Models
Shown to stimulate satellite cell proliferation and accelerate repair after muscle injury [2].
Age-Related Muscle Loss Research
MGF levels decline with age; supplementation is used in models to investigate sarcopenia reversal [3].
Regenerative Medicine Applications
Explored for its potential to enhance muscle regeneration in degenerative diseases [4].
References
Goldspink G (2005). Mechanical Signals, IGF-1 Isoforms, and Muscle Growth. J Appl Physiol.
https://journals.physiology.org/doi/epdf/10.1152/physiol.00004.2005Hill M et al. (2003). MGF Expression and Muscle Repair Following Injury. J Physiol.
https://www.physoc.org/magazine-articles/mgf-a-local-growth-factor-or-a-local-tissue-repair-factor/Owino V et al. (2001). IGF-1 Isoforms and Age-Related Muscle Loss. FASEB J.
https://www.sciencedirect.com/science/article/pii/S0014579301028253McKay BR et al. (2008). Synergistic Effects of IGF-1 and MGF on Muscle Cells. Am J Physiol Cell Physiol.
https://link.springer.com/chapter/10.1007/978-3-319-27511-6_2
Mechanism of Action (How MGF Works)
Local IGF-1 Splice Variant: Expressed rapidly in muscle after mechanical load, acting as an autocrine/paracrine growth signal [Goldspink 2005].
Satellite Cell Recruitment: Stimulates satellite cell proliferation and differentiation, aiding muscle regeneration [Hill 2003].
Transient Anabolic Signaling: Short half-life allows for rapid, localized muscle adaptation without systemic effects [Owino 2001].
Synergy with IGF-1Ea: Works with other IGF-1 isoforms to complete the hypertrophic response [McKay 2008].
References
Goldspink G (2005). Mechanical Signals, IGF-1 Isoforms, and Muscle Growth. J Appl Physiol.
https://journals.physiology.org/doi/epdf/10.1152/physiol.00004.2005Hill M et al. (2003). MGF Expression and Muscle Repair Following Injury. J Physiol.
https://www.physoc.org/magazine-articles/mgf-a-local-growth-factor-or-a-local-tissue-repair-factor/Owino V et al. (2001). IGF-1 Isoforms and Age-Related Muscle Loss. FASEB J.
https://www.sciencedirect.com/science/article/pii/S0014579301028253McKay BR et al. (2008). Synergistic Effects of IGF-1 and MGF on Muscle Cells. Am J Physiol Cell Physiol.
https://link.springer.com/chapter/10.1007/978-3-319-27511-6_2
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