Epithalon
Price range: $ 35.00 through $ 89.00
All products are for laboratory research purposes only. Not for human consumption, medical, or veterinary use. ION Peptides does not condone or support the use of peptides outside of controlled scientific research. By purchasing, you acknowledge that you are a qualified researcher or institution. You must be 21 or older.
Epithalon (Epitalon, Epithalamin)
Research-Grade Tetrapeptide
Tagline: Telomere & Longevity Research
Product Description
Epithalon (also known as Epitalon or Epithalamin) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the natural pineal gland peptide Epithalamin. It has been extensively studied in Russian gerontology research for its potential to activate telomerase, support cellular longevity, and regulate circadian rhythm genes.
Researchers use Epithalon to explore telomere length maintenance, oxidative stress reduction, neuroendocrine function, and age-related gene expression in cellular and animal models.
For Laboratory and Scientific Research Use Only. Not for Human Consumption.
Why Researchers Choose Epithalon
Well-Studied Tetrapeptide: Derived from decades of Russian biogerontology research.
Telomerase Activation: Reported to lengthen telomeres in human somatic cell cultures.
Anti-Oxidative & Anti-Senescence Research: Studied for reducing oxidative stress markers and delaying cellular aging.
Neuroendocrine Effects: Supports research on melatonin regulation and circadian rhythms.
Batch Verified: Identity and purity (≥98%) confirmed for consistency and reproducibility.
Research Data & Handling Tips
Reconstitution: Reconstitute with sterile water or bacteriostatic water; swirl gently until dissolved.
Solubility: Highly soluble in aqueous solutions.
Storage: Store lyophilized peptide at -20 °C. After reconstitution, aliquot and keep at -80 °C.
Stability: Stable for 24 months (lyophilized); use within 4–8 weeks after reconstitution.
Important Note
For laboratory and scientific research only. Not for human consumption, veterinary use, or diagnostic purposes.
| Chemical Formula | C₁₄H₂₂N₄O₉ |
| Molecular Mass | 390.35 Da |
| CAS Number | 307297-39-8 |
| Vial Size | 5 mg, 10 mg, 20 mg |
| Form | Lyophilized peptide powder |
| Solubility | Water, PBS, or compatible buffer |
| Shelf Life | 24 months (lyophilized) |
| Handling | Protect from light; avoid repeated freeze-thaw cycles |
| Intended Use | For preclinical and in vitro research only |
| Storage | -20 °C (dry powder), -80 °C (after reconstitution) |
Research Applications
Telomere Length & Cellular Aging
Epithalon has been shown to activate telomerase, elongate telomeres, and extend proliferative capacity of human somatic cells in vitro [1].
Antioxidant & Stress Response Studies
Reported to normalize antioxidant enzyme activity and reduce lipid peroxidation in aging animal models [2].
Neuroendocrine & Circadian Rhythm Research
Supports pineal gland function and melatonin synthesis, making it relevant for circadian rhythm and sleep-wake cycle studies [3].
Longevity & Age-Related Disease Models
Animal studies suggest life-span extension and improved reproductive function in aging rodents [4].
References
Khavinson V et al. (2003). Epithalon Induces Telomerase Activity and Telomere Elongation in Human Somatic Cells. Bull Exp Biol Med.
https://link.springer.com/article/10.1023/A%3A1025493705728Anisimov VN et al. (2001). Effect of Epithalon on Antioxidant Enzymes in Aging Rats. Biogerontology.
https://link.springer.com/article/10.1023/A%3A1025114230714Khavinson V et al. (2002). Pineal Peptides and Melatonin Regulation. Neuroendocrinology Letters.
https://www.nel.edu/Neuro-endocrinology-letters-23-Suppl-3/Anisimov VN et al. (2000). Epithalon Increases Lifespan in Rodent Models. Bull Exp Biol Med.
https://www.sciencedirect.com/science/article/abs/pii/S0047637400002177
Mechanism of Action (How Epithalon Works)
Telomerase Activation: Stimulates telomerase reverse transcriptase (TERT) expression, maintaining telomere length [Khavinson 2003].
Gene Expression Modulation: Influences expression of genes related to stress resistance and cell cycle regulation [Anisimov 2001].
Melatonin Secretion Support: Regulates pineal function, increasing nighttime melatonin release [Khavinson 2002].
Antioxidant Defense Enhancement: Normalizes superoxide dismutase (SOD) and glutathione peroxidase activity [Anisimov 2001].
Anti-Senescent Effects: Reduces accumulation of senescent cells in aged tissues [Anisimov 2000].
References
Khavinson V et al. (2003). Epithalon Induces Telomerase Activity and Telomere Elongation in Human Somatic Cells. Bull Exp Biol Med.
https://link.springer.com/article/10.1023/A%3A1025493705728Anisimov VN et al. (2001). Effect of Epithalon on Antioxidant Enzymes in Aging Rats. Biogerontology.
https://link.springer.com/article/10.1023/A%3A1025114230714Khavinson V et al. (2002). Pineal Peptides and Melatonin Regulation. Neuroendocrinology Letters.
https://www.nel.edu/Neuro-endocrinology-letters-23-Suppl-3/Anisimov VN et al. (2000). Epithalon Increases Lifespan in Rodent Models. Bull Exp Biol Med.
https://www.sciencedirect.com/science/article/abs/pii/S0047637400002177
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